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Akhanda 2 Box Office: Balakrishna’s Film to Open in Record Numbers With New Ticket Prices_我的网站

一 |     阿尔茨海默病（AD）是一种使人衰弱的渐进性疾病，开始时是轻微的记忆丧失，慢慢地破坏了认知功能和记忆。它目前没有治愈方法，预计到2050年将影响全球1亿多人。

二 | 在美国，根据国家老龄化研究所的数据，AD是老年人痴呆的主要原因，也是第七大最常见的死亡原因。    Balakrishna’s film Akhanda 2 was originally supposed to hit the screens on December 5. Back then, as the film neared its release, the advance bookings and ticket sales were average at the box office. But after the film was postponed by a week, Akhanda 2 is witnessing a massive turnaround for advance booking.          Akhanda 2 buzz is palpable     A couple of weeks ago, the buyers of Akhanda 2 were under the impression that Balakrishna was overdue to deliver something big. They felt that Akhanda 2 wasn’t generating the desired buzz to trigger ticket sales, especially after the first instalment was a blockbuster. But things have changed dramatically within a week. The postponement of Akhanda 2 by Madras High Court due to an unpaid earlier arbitration by the producers became the hottest topic. Filmmakers’ subsequent negotiations with concerned stakeholders, followed the court clearance have all added to film’s the buzz. The advance bookings that have opened in Telangana (Nizam), Andhra Pradesh and overseas is a clear indication of the development. Earlier, before the December 5 release, the numbers weren’t this staggering. But the buzz is palpable as the film is set to open in record numbers.          Akhanda 2 ticket prices     Earlier, the G.O. was not issued by Telangana even hours before the scheduled premieres. But now it has issued a fresh G.O. in relation to the ticket rate hike for Balakrishna’s Akhanda 2. The bookings for the premiere shows are scheduled from 9 PM (Thursday) and will be priced around Rs. 600. The hikes are allowed only till the first three days. For regular shows, the ticket prices have increased by Rs. 50/- (including GST) in single screens and Rs. 100/- (including GST) in multiplexes. So the new fares are set at Rs. 395/- in multiplexes and Rs. 227/- in single screens. The revised G.O. also makes it clear that Akhanda 2 team should give 20 percent of the incremental revenue to the ‘Telugu Film Industry Employees Federation’ (as suggested by Chief Minister Revanth Reddy). In Andhra Pradesh too, the government gave permission for premiere (December 11) tickets to be priced at Rs 600 (including GST). From December 12, for the next 10 days, an approval of Rs 100 and Rs 75 for multiplexes and single screens respectively, were approved.Also Read: Akhanda 2 Release Crisis: Balakrishna to Cut Down His Remuneration?。正在进行的阿尔茨海默氏症研究集中在两个关键的神经毒性蛋白上：淀粉样β（Aβ）和tau。尽管这些蛋白质已被证明与AD有关，但Aβ和tau的水平并不能持续解释或与一些疾病患者的认知能力下降的严重程度相关。作为麻省总医院布里格姆医疗系统的创始成员之一，布里格姆妇女医院的研究人员着手确定其他可能直接参与AD基本方面的蛋白质，如突触损失和神经变性。他们将实验室的神经元暴露在大约40人的大脑提取物中，这些人要么患有AD，要么在Aβ和tau水平较高的情况下受到保护，要么在大脑中很少或没有Aβ和tau时受到保护。

三 | 科学家们发现并验证了神经节苷脂GM2激活剂（GM2A）是一种能够减少神经元发射并诱发神经元完整性丧失的蛋白质。这些蛋白质的特征可能有助于AD的病因、疾病的进展，或两者都有。高级作者、神经学系的Tracy Young-Pearse博士说："我们的数据有助于确定一种可能与阿尔茨海默病的发病机制有关的新的和潜在的重要蛋白质。

四 | 有趣的是，GM2A以前被认为是一种与Tay-Sachs病非常相似的溶酶体储存障碍的致病因素，Tay-Sachs病是另一种像AD一样破坏神经元的疾病。

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